Malignancy and Chronic Leg Ulcers

Chronic leg ulcers.

'If you chance to have in Cure an Apostume, that by the malignitie of the humors, or other evill disposition of the body changeth itselfe into a rebellious Ulcer . .. or that such an Ulcer come to thy hand from another Artist, be not out of hope to cure the same. For if Nature be not utterly thy enemy . . . proceeding as followeth, thou shalt be able to cure the disease, by the helpe of God.' J...

Malignancy in Scars, Chronic Ulcers, and Sinuses.

A collection of 44 cases of malignancy in scars, chronic ulcers, and sinuses, included the following predisposing lesions: a 20-year-old sinus from ischial bursitis, a 23-year-old bed sore, a congenital gumma about 50 years old, three burn scars (average age of scar 56 years), 11 sinuses from chronic osteomyelitis, and 27 chronic ulcers of the leg. The osteomyelitis cases included two rapidly f...

Chronic Venous Ulcers of the Leg

Evidence-based treatment of chronic leg ulcers.

BACKGROUND Chronic leg ulcers are defined as those that show no tendency to heal after 3 months of appropriate treatment or are still not fully healed at 12 months. In this article, we present an approach to the challenging problem of chronic leg ulcers that is based on the principles of evidence-based medicine, i.e., the explicit use of the best available scientific evidence as a guide to trea...

Cyclin A expression in chronic leg ulcers.

Normal wound repair involves an initial inflammatory phase characterized by neutrophil infiltration and excessive protease activity, which is followed by macrophage migration, angiogenesis and keratinocyte proliferation and migration. In contrast to acute wounds, chronic ve-nous ulcers fail to follow this timely pattern of events and persist in a chronic inflammatory stage involving high protea...